Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. Data and theory point to mainly additive genetic variance for complex traits. An atlas of genetic correlations across human diseases and traits. The genetic architecture of type 2 diabetes. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. An android body fat distribution in females impairs the pregnancy rate of in-vitro fertilization-embryo transfer. Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Rare and low-frequency coding variants alter human adult height. Population genetic differentiation of height and body mass index across Europe. Genetic studies of body mass index yield new insights for obesity biology. Defining the role of common variation in the genomic and biological architecture of adult human height. The UK10K project identifies rare variants in health and disease. A class of Bayesian methods to combine large numbers of genotyped and non-genotyped animals for whole-genome analyses. in Handbook of Markov Chain Monte Carlo (eds Brooks, S., Gelman, A., Jones, G. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Estimation of SNP heritability from dense genotype data. Improved heritability estimation from genome-wide SNPs. The genetic architecture of gene expression in peripheral blood. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. Inference on the genetic basis of eye and skin color in an admixed population via Bayesian linear mixed models. Polygenic modeling with Bayesian sparse linear mixed models. Whole-genome regression and prediction methods applied to plant and animal breeding. Simultaneous discovery, estimation and prediction analysis of complex traits using a Bayesian mixture model. Extension of the Bayesian alphabet for genomic selection. Large-scale genomics unveils the genetic architecture of psychiatric disorders. Genome partitioning of genetic variation for complex traits using common SNPs. Common SNPs explain a large proportion of the heritability for human height. Estimating missing heritability for disease from genome-wide association studies. Finding the missing heritability of complex diseases. 10 years of GWAS discovery: biology, function, and translation. The contribution of rare variation to prostate cancer heritability. Evolution in health and medicine Sackler colloquium: genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Are rare variants responsible for susceptibility to complex diseases? Am. The hitch-hiking effect of a favourable gene. The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Theoretical models of selection and mutation on quantitative traits. We conclude that negative selection acts pervasively on the genetic variants associated with human complex traits. The significant estimates of the relationship between effect size and minor allele frequency in complex traits are consistent with a model of negative (or purifying) selection, as confirmed by forward simulation. We detect significant ( Pā<ā0.05/28) signatures of natural selection in the genetic architecture of 23 traits, including reproductive, cardiovascular, and anthropometric traits, as well as educational attainment. We apply the method to 28 complex traits in the UK Biobank data ( Nā=ā126,752) and show that on average, 6% of SNPs have nonzero effects, which in total explain 22% of phenotypic variance. We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelated individuals using genome-wide SNP data.
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